Manufacturer,provider and supplier of
Recombinant Human Interferon alpha 2a,rHuIFN α-2a

Source    A DNA sequence encoding the mature human IFN α-2a protein expressed in yeast.
Molecular Mass 19.2kD
Purity      > 97%, as determined by SDS-PAGE and HPLC method.
Endotoxin Level    <0.1EU/μg of the cytokine as determined by the LAL method.
Activity   Bioactivity is detected using cytopathic effect inhibition assay method,WISH cell (a heteroploid human amnion cell line) as dependent cell strain.The specific activity shall be not less than 1.0?08 IU/mg.
Formulation Lyophilized from a 0.2μ m filtered solution in 50mM Phosphate buffer sodium containing 50μg of human serum albumin per 1μg of cytokine.
Reconstitution It is recommended that sterile ddH2O containing at least 0.1% human serum albumin or bovine serum albumin be added to the vial to prepare a stock solution of no less than 1 μg/mL of the cytokine.
Storage Lyophilized samples are stable for greater than six months from date of receipt at -20ºC to -70ºC.
Upon reconstitution, this cytokine can be stored under sterile conditions at 2- 8ºC for one month or at -20ºC to -70ºC in a manual defrost freezer for three months without detectable loss of activity.
Avoid repeated freeze-thaw cycles.

Size available: 100μg,1.0mg

Related
1 Recombinant Human Interferon alpha 2b (Reagent)

2 Recombinant Human Interferon alpha 2b (Material)

Human Interferon Alpha-2a is a single polypeptide chain of 165 amino acids residues,containing 4 Cys to form two disulfide bonds at positions of Cys 1-Cys 29 and Cys 98-Cys 138,and it has a molecular mass of approximately 19kD.
IFN can exert certain cell activities through binding to specific cell surface receptors, as firstly induce to develop special proteins, such as protein kinase and 2 ?/font>, 5?/font>-oligo polyadenylic acid synthase etc. The unique character of two enzymes is that they can be activated respectively by double chains RNA to produce the effect of selfphosphorylation. INF can also enhance phagocytosis activity of macrophage and special toxicity of lymphocyte to target cells to cause immunoloregulation.
Its biological effects contains: (1) Anti-virus: INF α has broad-spectrum anti -virus effect; (2)Cytostatic effect to certain cells; (3) Immunoloregulation effect: accelerate the expression of MHC antigen by most cell and active NK cell and CTL.(4) Repress and kill tumor cells: INF-α kill the tumor cells through accelerating the immunological function and enhancing the killing ability of macrophage, NK and CTL.